There has been an intense amount of focus on probiotics in both the medical literature and mainstream media over the last decade. Probiotics (the beneficial microbes that reside throughout our body but especially in our gut) are without a doubt one of the key factors when it comes to good health. However arguably more important are prebiotics, the foods that feed our probiotic colonies and encourage them to flourish.

Probiotic supplements are guns for hire

One of the main reasons for focusing on prebiotics rather than probiotics for long term health is that probiotic supplements only provide transient benefit to the good bacteria in our gut. Think of them as highly trained troops that can enter an area of conflict and help to restore the peace, but then inevitably leave after a relatively short time. They are not native to the environment they are deployed to, and thus ultimately they are told to depart.

The locals need to get stronger or the conflict will sustain

Following the same theme, if all we do to restore law and order in a conflict zone is place in foreign troops without supporting the desirable local population, then as soon as those troops leave the conflict starts again. This is where prebiotics are so crucial – they provide the nutrition to the native population so they can strengthen and fight the conflict themselves in future.

Sometimes you need a targeted strike before prebiotics are used

One caveat to the generally beneficial use of prebiotics is in those patients who have SIBO (small bacterial overgrowth). In this example, generally beneficial bacteria may have migrated into the small intestine where they have become problematic. If these organisms are fed, they will likely produce excessive gas and toxicity as a by-product of metabolism that will exacerbate the patients symptoms. In this case, these organisms will need to be cleared from the small intestine with the use of targeted herbs and nutrients before prebiotic therapy is used.

The top 5 prebiotic foods to include in your diet

Although there are many good powdered formulas that provide a mix of beneficial prebiotics, the best way to feed your healthy gut flora is with a wide variety of prebiotic foods in your diet on a daily basis. So without further ado, here are the top 5 easily accessible foods that give your gut the best dose of prebiotics for continued gut health:

  1. Garlic and onion – ok ok I cheated straight out of the gate and included two foods here but they both provide high levels of a crucial type of prebiotic called fructans. Garlic also has amazing antimicrobial properties and can help clear infection while it strengthens your beneficial flora.
  2. Asparagus – depending on your particular makeup of enzymes, you may find that your housemates complain about your asparagus consumption if they have to use the toilet after you, however your beneficial flora certainly won’t complain. Asparagus provides both fructose and fructans, a double whammy of goodness for your gut bugs.
  3. Legumes in general, especially chickpeas, lentils and red kidney beans – these have high levels of galactans, further diversifying the types of prebiotic you provide.
  4. Stone fruits such as nectarines, peaches and plums – fruits in general have high levels of fructose which is another important prebiotic, however these stone fruits are powerhouses due to their provision of another category of prebiotics called polyols.
  5. Artichokes – These are arguably the most powerful prebiotic food on the planet, however I’ve listed them last as they can be less readily available than other fruits and vegetables. They provide both fructose and fructans in high levels.

So when you’re next browsing the supermarket fresh produce section, spare a little thought for your friendly gut bacteria and choose some foods that give them a boost. They’ll pay you back with good health for years to come.

In wellness,

James Marr

The gut / brain connection

The gut / brain connection has been receiving increasing levels of attention in medical research over the last decade. It’s now becoming clear that disruption in the gut can cause a range of not just physical but also psychological issues. These include depression, anxiety, brain fog, and ADD / ADHD. These two organ systems, once considered completely independent of each other, are now known to be tightly linked via the nervous system, hormones, and neurotransmitters. So much so that our gut is now often referred to as our ‘second brain’.

The microbiome is a neurotransmitter factory

The production and regulation of key neurotransmitters such as serotonin and dopamine is incredibly dependent on a balanced range of flora in our gut. For instance, more than 95% of the serotonin produced in our body comes from our gut bacteria, and 50% of our dopamine is produced in the gut. Disruptions to the balance of our microbiome through poor diet, antibiotic usage, and infection can all severely impact neurotransmitter production, having profound effects on our mental health.

Gut dysbiosis and nutrient deficiency

Another factor impacting psychological behaviour as it relates to our gut is nutrient malabsorption. We rely on both the structural integrity as well as the composition of our gut bacteria to facilitate the absorption of nutrients from the food we consume. When gut disruption occurs, this can result in quite severe nutrient deficiencies (even in the presence of a healthy diet). Without key nutrient components, we cannot produce adequate amounts of key neurotransmitters, thus resulting in many possible behavioural issues.

Detailed investigation is key

If any of my patients present with behavioural issues such as ADD or ADHD, and they also have symptoms of gut issues, ordering a comprehensive microbiome map test is always my first area of investigation. Identification of infection, poor microbial balance, leaky gut, and toxicity are all key areas that will need to be treated. Addressing these issues can have a profound effect on behavioural problems, so much so that I have taken to referring to our gut as our ‘primary brain’!

If you or any loved ones have been diagnosed with ADHD / ADD, or any other spectrum disorder such as Autism, and there are clear indicators of a dysfunctional gut, I strongly encourage you to seek further thorough investigation and analysis of the microbiome and to gently restore it’s healthy function. You could be amazed at the benefits it brings.

In wellness,

James

A universe of life

The volume of organisms present in the typical human gut is staggering – between 10 and 100 trillion microbial cells form this diverse ecosystem within our bodies. When they are balanced and working in concert, they provide a wide range of benefits that keep us healthy and happy. These benefits include the production of feel good neurotransmitters such as dopamine and serotonin, appetite regulation through the production of leptin and ghrelin, blood sugar regulation through promotion of insulin sensitivity, hormone regulation via alterations in oestrogens and androgens, and stress reduction via regulation of cortisol production.

Imbalance leads to disease

However, if this ecosystem loses it’s balance then disease will follow. Certainly disease of the gastrointestinal system, but also systemic disease of the entire body. A proliferation of potentially harmful organisms that should generally be kept in check by the appropriate levels of beneficial ones can be the triggering event that results in all of the leading causes of mortality: heart disease, cancer, diabetes, and dementia.

Diversity is strength

A diverse microbiome is capable of performing more beneficial functions for the body. Diversity gives greater resistance to colonisation by infective organisms. Diversity also creates more checks and balances that keep physiological processes performing optimally. The greatest threats to microbial diversity are a poor diet, environmental toxins, and the use of antibiotics and many other pharmaceutical medications.

LPS and metabolic endotoxemia

An imbalanced microbiome will produce higher levels of toxicity, particularly a compound called lipopolysaccharide or LPS. In addition, an imbalanced microbiome will cause damage to the gut lining. This damage allows the infiltration of LPS into the blood stream, thus circulating throughout the body and triggering widespread immune reactivity and inflammation. It is this chronic inflammation that can trigger a range of disease processes both within the gut as well as throughout the body.

What can be done?

The core principles of restoring a diverse microbiome are simple:

  • Eat a diet high in a wide variety of vegetables and fruits (these should compromise at least 50% of your diet).
  • Avoid excessive levels of fat, especially vegetable fats such as canola oil (olive oil is the exception here and is very beneficial). Animal fats should be kept to a minimum, but never choose an animal product that has been processed to remove naturally occuring fat eg choose full cream dairy over skim or reduced fat versions.
  • Only use antibiotic medications when absolutely neccessary
  • Avoid environmental chemicals wherever possible (especially household cleaning products as well as personal products such as soaps, perfumes and make-ups)

Infection eradication

Beyond the core principles mentioned above, it may be neccessary to identify and remove pathogenic ‘trouble makers’ from your gut (see my article on SIBO to understand more). In this case, I strongly recommend finding a qualified practitioner that can order detailed stool testing to determine the specifics of both detrimental and beneficial organisms present (I have found the microbiome mapping test I offer in my clinic to be the clear winner in this case). These results will steer the specific botanical and nutritional agents used in clearing the identified infection, as well as the key probiotic strains required to bolster levels of beneficial organisms. Also, repairing the gut lining is an important step in recovery – the amino acid glutamine can be beneficial with this.

Your gut is truly the key to health

The most important take away from all of this: if you have any symptoms of gut dysfuction (reflux, IBS, diarrhea or constipation etc) this is not normal, and could lead to further health complications. There is highly effective treatment available, and restoring your gut to normality should be the priority for a long and healthy life.

Do you have any stories of how gut issues impacted other areas of your health? Or perhaps you have questions – feel free to ask or comment!

In wellness,

James Marr

With so many acute and chronic gut issues prevalent in our society today, it pays to know the best supplements to both soothe and heal an inflamed and damaged gut. These are my top 5 supplements to help repair gut tissue. And always remember that symptom relief is only the first step on the healing journey – uncovering the underlying cause of dysfunction is the path to truly creating lasting and effective health.

Cooking meals for two kids under the age of 10 can be a real challenge – tastes seem to change on a daily basis! However this recipe continues to be a family favourite. It’s one of the few dishes that the kids polish off (and sometimes even ask for second helpings – gasp).

As an added bonus, it’s a super quick and easy recipe too, yay.

If you’re vegetarian or vegan, you can substitute the chicken in the recipe for chick peas and the chicken stock for a vegetarian alternative.

You can download a PDF of the recipe below the video.

Enjoy!

Once thought of as purely a tool for body builders to repair and gain more muscle, glutamine is now known to have wide ranging benefits for overall health. Glutamine is an amino acid, meaning it is a building block of larger protein structures. It is considered a conditionally essential nutrient – while we can typically meet out glutamine needs through diet alone, this changes when we experience damage or stress. In these states, additional supplementation can yield impressive results.

Glutamine is typically referred to in two different ways: glutamine or l-glutamine. But don’t be confused as these two terms actually refer to the same thing. There is a different form called D-glutamine however this has no biological activity and hence is not used in any supplemental products.

Antioxidant support

Glutamine is crucial for the production of glutathione, one of the most important antioxidants produced in every cell of the body. Glutathione actively negates free radical damage, helping to preserve cellular function and reduce ageing. This study showed a 50% improvement in glutathione stores in patients undergoing a standardised medical procedure while supplementing with glutamine.

Immune support

Although the exact mechanisms are still poorly understood, it seems that glutamine can enhance the immune system via improvements in both lymphocyte and interleukin-6 function. These cells help the immune system both rapidly respond to a threat, and target a specific pathogen on an ongoing basis. This study shows a clear correlation between glutamine supplementation and ” a significant reduction in hospital mortality and hospital length of stay. “

Acid-base balance maintenance

When the body becomes too acidic, glutamine can be broken down into glutamate and ammonia. Ammonia can then act as an alkalising agent to shift the body from an acidic to a more alkaline state. With most standard western diets made up of excessive meat, dairy, grains and sugar (all highly acidifying foods) and a lack of fresh fruits and vegetables (all highly alkalising foods), an extra alkalising boost wouldn’t go astray.

Intestinal repair

This is my favourite use for glutamine – it can stimulate the growth and repair of the intestinal mucosa, healing what is widely known as ‘leaky gut’. Glutamine specifically strengthens the bonds between the cells of the gut – think of it as intestinal superglue! So many of my patients suffer from damage to their gut wall, and understandably so as there are many factors which can adversely affect it. These include alcohol, stress, infections, toxins, and many pharmaceutical drugs. Glutamine can get to work healing the gut while I investigate and resolve the cause of a patient’s health issues.

Conditions that may directly or indirectly relate to leaky gut can include:

  • IBS
  • Inflammatory bowel disease
  • Chronic urticaria
  • Diabetes
  • Rheumatoid arthritis
  • Coeliac disease
  • Cystic fibrosis
  • Asthma
  • Major burn injuries
  • Heavy metal toxicity
  • and many more

Food sources of glutamine

Typical food sources of glutamine are animal and plant proteins. These may include fish, chicken, beef, tofu, miso, tempeh, and legumes.

Supplementing with glutamine

Glutamine will typically come in a powdered form. Dosage can be anywhere from a teaspoon to several tablespoons per day – a general rule when healing leaky gut is to dose around 0.3 to 0.5g of glutamine per kg of bodyweight, per day (ideally in divided doses). Be cautious with tableted or encapsulated forms of glutamine as it is extremely difficult to get an appropriate dosage with this form of administration.

Cautions with glutamine supplementation

High doses of glutamine may increase blood levels of glutamate, which can then act as a neuro-excitory stimulant. Thus excessive dosing of glutamine should be avoided in those with neurodegenerative disease (multiple sclerosis, ALS etc).

Conclusion

Glutamine is one of my favourite supplements for gut health. With so many chronic diseases tracing their origin back to the integrity of our gut lining, glutamine can be a great asset in improving health and restoring function. Have you had any experience using glutamine to improve your health? Comment below to share your story.

In wellness,

James

CIRS (also known as biotoxin illness) is a cluster of symptoms relating to biotoxin exposure in genetically susceptible individuals. So lets break down the three parts of this description:

Symptoms

Symptoms of CIRS can cover many body systems and may be incredibly diverse. Some of the more common ones may include:

  • Impaired memory and difficulty with word finding
  • Congested sinuses and shortness of breath
  • Deep persistent fatigue
  • Extreme thirst
  • Weakness and body aches
  • Joint pain and muscle cramps
  • Dizziness
  • A metallic taste in the mouth
  • Diarrhea with abdominal pain
  • Heightened skin sensitivity

Biotoxins

Mould is the most commonly associated biotoxin when it comes to CIRS, however there are a number of other toxins that may trigger symptoms:

  • Bacteria (such as borellia from tick or other insect bites)
  • Parasites (such as babesia as above)
  • Dinoflagelette algae which produces the Ciguatera toxin (from ingestion of infected seafood)
  • Pfiesteria or Cyanobacteria (from contact with contaminated water, particularly in areas of high fish kills)

Genetic susceptibility

To determine if a patient is genetically susceptible to CIRS, a Human Leukocyte Antigen test is run. This looks for the sequencing present on a set of genes which regulate the immune system. Essentially if there is a coding issue on this set of genes, one part of the immune system will recognise that there is a biotoxin present in the body and produce inflammation to deliver antibodies to the site. However the other part of the immune system that is responsible for the antibody production fails to deliver. The biotoxin stays in place, with a perpetual cycle of inflammation responsible for the symptoms emerging.

CIRS is an issue which seems to be rapidly increasing in prevalence – even in the last few years I have seen a significant increase in patients presenting with this chronic and debilitating health concern. I believe this is due to an increasingly toxic environment, with those genetically susceptible individuals finally reaching a threshold of exposure that proves to be the ‘straw that breaks the camels back’.

So what to do about CIRS?

The first step is to find a qualified health practitioner that can review your history and symptoms to rule out any other health issues. If CIRS is indicated, I always start with the genetic testing outlined above as this can be a definitive way to rule out CIRS if the genetics are not present. If the genetics are present, I will start treatment with an effective toxin binder to help clear any free floating toxicity from the gut. Detoxification support is a key requirement and will involve liver, kidney, gut and mitochondrial support. Personalised treatment for specific symptoms is crucial and can vary widely based on the individuals presentation. Immune support is helpful in the long term to bolster inadequate antibody production.

Perhaps most important of all is to identify the source of toxin exposure and eliminate it. This will often be mould present in the home or workplace, which may be remediated with the help of an appropriately qualified professional (and no, bleach will not kill or remove the mould, only make it harder to see!). There have been occasions where the infestation is so extensive a patient has been forced to sell their home or change jobs.

Elimination of ongoing biotoxin exposure becomes more difficult when it is from an infective organism inhabiting the body – however with the right herbal, nutritional and lifestyle therapy, this can certainly be achieved.

So if you have mould present in the home or workplace, a history of tick or spider bites, or known exposure to dirty stagnant bodies of water, and you check a number of boxes in the symptom list above, I’d suggest getting screened for CIRS ASAP – it may just give you back that level of health you have been missing for so long.

In wellness,

James

It’s that time of year again – everyone seems to be promoting their latest detox regimen for a new you in 2020. Most of these involve extreme fasting, supplementation, or major shifts in behaviour. But detoxing doesn’t have to be complicated – your body does a pretty good job of it day in and day out without needing the latest fad or newest technology.

Most of the toxification issues that challenges our bodies come from one source – our food. Excessive sugar, industrial plant oils, conventionally grown produce, and animal products all take their toll on our detoxification capacity. When our body becomes overwhelmed, health issues will follow.

So to give your body a break from the toxicity and allow it to cleanse itself, all you need to do is to focus on a purely plant based diet for a period of time (I’d recommend starting with 3 days. This can be extended once you’ve got the hang of things). Ideally the fruits and vegetables you source are organic as much as possible, or at least adhere to avoiding the Dirty Dozen list of the most heavily sprayed crops.

Also aim for a variety of fresh produce (I’d recommend at least 8 different types of veg and 5 different types of fruit per day), and use the colours of the rainbow to dictate which foods to pick. There should be a variety of colour on every plate, and white foods (eg potatoes) should be generally avoided.

The influx of vitamins and minerals will give your body’s cells the nutrition they need to ‘clean house’, and the fiber will help bind the toxins as they pass through the gut to make sure they get eliminated. Easy peasy. And there is no need to limit food intake – eat as much fruit and veg as it takes to help you feel full.

Be sure to drink plenty of water, ideally around 2.5 liters per day. Even better, squeeze some fresh lemon or lime into every glass for an extra detox kick.

And just for the record I do think that from a health perspective a balanced diet that includes a small amount of occasional lean animal meat (with less red meat), as well as nuts, seeds, legumes and healthy fat predominantly in the form of olive oil, is the best way to go over the long term.

So go ahead, whip up that blueberry, watermelon and pineapple smoothie for breakast. Shred some carrot, cucumber and lime for a snack. Create a 5 veg salad for lunch. And have some zucchini noodle pasta with fresh tomato, basil and baked sweet potato for dinner.

Please let me know if you have any good detox strategies that have worked for you!

In wellness,

James

The power of positive thinking

Getting healthy seems to be a very physical act for most people. Eating healthier foods, exercising more frequently, avoiding alcohol and drugs – all of these things undoubtedly have a positive influence on our wellbeing. However changing our patterns of thinking, and understanding the profound effect this can have on our health, often seems to take a back seat. Working on negative thought processes, actively practicing forgiveness, taking twenty minutes out of our day to be still and quiet our racing minds – these small acts are placed way down the list of priorities.

The sceptical ego

I feel much of this procrastination regarding working on mental wellbeing is due to our ego. More specifically, the tendency of our ego to view anything that is not solid and visible as unimportant. It can be hard to convince ourselves that something intangible could be so central to our state of health, but luckily the science is catching up.

Studies on optimism

Multiple studies have shown a strong link between one’s level of optimism and lower incidence of many adverse health outcomes such as depression, memory deficit, multiple auto-immune diseases, and a general lengthening of life span. These studies have also shown a strong link between levels of optimism and improved immune function, as well as a 45% lower incidence of death from coronary artery disease.

Seven questions towards optimism

The following 7 questions can be helpful in retraining our brains towards optimism:

  1. What am I most happy about in my life right now?
  2. What am I most excited about in my life right now?
  3. What am I most grateful for in my life right now?
  4. What am I enjoying most about in my life right now?
  5. What am I commited to in my life right now?
  6. Whom do I love?
  7. What must I do today to acheive my long-term goal?

A daily practice

I love using a gratitude journal every evening to train my brain towards optimism and away from pessimism. It only takes a few minutes before bed to write down several things you were most grateful for during the day, or what you are looking forward to the following day. Done on a regular basis this has a profound ability to reprogram the brain.

Remember that just like improvements in the physical body through exercise, improvements in our mental health do not come about through one isolated attempt. Rather, regular daily practice over a long period of time will get the best results.

If you have a daily practice you use to help maintain optimism, please share it in the comments below.

In wellness,

James Marr